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Guanabenz
epoh
Reg. Dec 2007
Posted 2016-04-03 3:17 PM
Subject: Guanabenz



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Likes/dislikes, ever had it take the run out? Just got a bottle and was wondering what everyones thoughts were..
Also, can you give it orally and if so what is the dosage?
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Time2beat
Reg. Sep 2008
Posted 2016-04-03 5:39 PM
Subject: RE: Guanabenz



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 Bump...wondering the same. 
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streakysox
Reg. Jul 2008
Posted 2016-04-03 10:15 PM
Subject: RE: Guanabenz



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Use it all the time. Can be given orally. Ask your vet for correct dosage. It does not take the run out.
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epoh
Reg. Dec 2007
Posted 2016-04-04 9:35 AM
Subject: RE: Guanabenz



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Ok great thank you
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streakysox
Reg. Jul 2008
Posted 2016-04-04 9:38 AM
Subject: RE: Guanabenz



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sadly, I am the one who needs it. seriously
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doglady
Reg. Feb 2006
Posted 2016-04-04 9:23 PM
Subject: RE: Guanabenz


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streakysox - 2016-04-03 10:15 PM

Use it all the time. Can be given orally. Ask your vet for correct dosage. It does not take the run out.

I have never tried it orally. Do you use the same or more as if you were iv?
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streakysox
Reg. Jul 2008
Posted 2016-04-04 10:14 PM
Subject: RE: Guanabenz



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doglady - 2016-04-04 9:23 PM

streakysox - 2016-04-03 10:15 PM

Use it all the time. Can be given orally. Ask your vet for correct dosage. It does not take the run out.

I have never tried it orally. Do you use the same or more as if you were iv?

Vet told me 3cc orally. I would check with your vet.
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linds
Reg. Feb 2005
Posted 2016-04-05 7:35 AM
Subject: RE: Guanabenz


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Yes, please check with your vet on dosage. I know Guanabenz is sold in different concentrations, so this is very important.
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epoh
Reg. Dec 2007
Posted 2016-04-05 9:57 AM
Subject: RE: Guanabenz



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I have read different places where you can give it orally so I called my vet and asked. He said it wouldn't be effective orally, but though the dose was around 2cc IM (he said he needed to double check)? I initially thought it was IV? I was speaking with the receptionist who was relaying the info, so maybe there was a mix up there. Yes, ace isn't as effective orally, but I still notice a difference when I have given it orally.
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Time2beat
Reg. Sep 2008
Posted 2016-04-05 1:12 PM
Subject: RE: Guanabenz



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 Has anyone had any side effects using it?
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LiftandLook
Reg. Mar 2016
Posted 2016-04-05 2:18 PM
Subject: RE: Guanabenz


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We have used it on several different horses. it doesn't take the run out, it just inhibits them from getting their blood pressure up and getting far too excited for their own good. Some people swear once you start using it, the horse will become dependent on it. We have never had that experience. We have found that once the horse learns that certain situations won't kill them, we take it away. We have never had ill-effects from it.
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Time2beat
Reg. Sep 2008
Posted 2016-04-05 3:30 PM
Subject: RE: Guanabenz



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LiftandLook - 2016-04-05 3:18 PM We have used it on several different horses. it doesn't take the run out, it just inhibits them from getting their blood pressure up and getting far too excited for their own good. Some people swear once you start using it, the horse will become dependent on it. We have never had that experience. We have found that once the horse learns that certain situations won't kill them, we take it away. We have never had ill-effects from it.

Thank you. My good horse got ran into and almost knocked over at a rodeo a few months ago and he gets really nervous anytime we're near the alleyway now. He panics anytime a horse walks near him now. My vet suggested it as an option to help him relax so he can learn he's not going to die lol. I couldn't really find much info on it to make up my mind. How far out do you give it and about how long does it last?
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mollibtexan
Reg. Jan 2007
Posted 2016-04-05 9:19 PM
Subject: RE: Guanabenz



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Dosage depends on what MG you have.....most vets guess at dosage veteran barrel racers are best to lean on. What is your MG?
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mollibtexan
Reg. Jan 2007
Posted 2016-04-05 9:20 PM
Subject: RE: Guanabenz



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Any drug you can give IM you can give orally
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Time2beat
Reg. Sep 2008
Posted 2016-04-05 11:06 PM
Subject: RE: Guanabenz



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mollibtexan - 2016-04-05 10:19 PM

Dosage depends on what MG you have.....most vets guess at dosage veteran barrel racers are best to lean on. What is your MG?

Mine is 4 mg/ml
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rodeoveteran
Reg. Jan 2009
Posted 2016-04-06 10:52 AM
Subject: RE: Guanabenz



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Tried it years ago on a blown up futurity mare who ran scared. I finally resorted to trying different drugs with her , hoping to convince her that she could run and still be somewhat relaxed. I had already tried everything I knew and had sent her to two different trainers who both liked her so much they each started her from scratch and got her back broke to death (as she was already) but no difference when the adrenaline hit. I had also tried natural, B1, magnetic and other therapies to no avail.

At that time, the only form it was available in was pill and I had to crush it up, put it in 10cc of injectable B1 (and B1 by itself had zero affect), and inject IV. It only lasted a few hours, but it is the ONLY drug that seemed to help. However , after using it twice, and the fact that I could see chunks of pill in the syringe that went into the jugular, I just couldn't use it anymore. Had there been an injectable form at that time, I might have given it more of a chance.

Never thought that I would resort to drugs but that mare was SO nice and SO athletic and SOOOOO fast with a wonderful disposition to boot. I could figuratively kill the well known futurity person who blew her up.
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1left2right
Reg. Dec 2003
Posted 2016-04-06 11:17 AM
Subject: RE: Guanabenz


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I used it on a freak show. It was awesome the first time. Second time, someone got hurt and the race was stopped for too long and it had no effect by the time it was our turn.
I decided it was too much work to get the timing perfect.
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mollibtexan
Reg. Jan 2007
Posted 2016-04-06 12:33 PM
Subject: RE: Guanabenz



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The full dose is 20mg. So try 2 1/2cc which will be a half dose. No matter what don't give more than 20mg. So if you have 20mg it's 1cc if you have 4mg it's 5cc if you have 2mg it's 10cc if you have 8mg it's 2 1/2. I use it sometimes on horses that try so hard they scramble. I might only give 4mg.
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mollibtexan
Reg. Jan 2007
Posted 2016-04-06 12:36 PM
Subject: RE: Guanabenz



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Those numbers are full doses so to start out I would do a 1/2 dose.
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Time2beat
Reg. Sep 2008
Posted 2016-04-06 12:53 PM
Subject: RE: Guanabenz



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mollibtexan - 2016-04-06 1:33 PM The full dose is 20mg. So try 2 1/2cc which will be a half dose. No matter what don't give more than 20mg. So if you have 20mg it's 1cc if you have 4mg it's 5cc if you have 2mg it's 10cc if you have 8mg it's 2 1/2. I use it sometimes on horses that try so hard they scramble. I might only give 4mg.

And how far out do you give it? 
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mollibtexan
Reg. Jan 2007
Posted 2016-04-06 3:18 PM
Subject: RE: Guanabenz



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30-45 min out
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Shorty 2
Reg. Apr 2005
Posted 2016-04-06 3:22 PM
Subject: RE: Guanabenz


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mollibtexan - 2016-04-06 1:18 PM

30-45 min out

Just to clarify for me, you're talking about the oral dosing, correct? Not familiar with the oral, since had only heard about the IV Guanabenz.
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soonergirl98
Reg. Oct 2009
Posted 2016-04-06 4:36 PM
Subject: RE: Guanabenz



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I recently had a discussion with a vet regarding whether to use Guanabenz or Sedivet for a horse that has serious anxiety problems from being run while hurt by a previous owner. The vet said Guanabenz actually lowers blood pressure and some will use it in place of low doses of lasix and Sedivet was designed just for anxiety and will not lower BP.
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mollibtexan
Reg. Jan 2007
Posted 2016-04-06 9:39 PM
Subject: RE: Guanabenz



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Shorty 2 - 2016-04-06 3:22 PM

mollibtexan - 2016-04-06 1:18 PM

30-45 min out

Just to clarify for me, you're talking about the oral dosing, correct? Not familiar with the oral, since had only heard about the IV Guanabenz.

I'm not exactly sure about that. I always do IV when I use it. If you do oral you might do further out. Try this at home first to see the effects you get.
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mollibtexan
Reg. Jan 2007
Posted 2016-04-06 9:44 PM
Subject: RE: Guanabenz



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Setivet was not designed for anxiety although it is used for such in low doses. Acepromazine is designed for anxiety.
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bbm85
Reg. Apr 2016
Posted 2016-05-10 3:48 PM
Subject: RE: Guanabenz


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A little late to join the conversation on this thread but what is the difference between Guanabenz and Chlorpromazine ?
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barrelbasher
Reg. Apr 2007
Posted 2016-05-10 8:13 PM
Subject: RE: Guanabenz



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Make sure if you plan to use guanabenz orally that it is compounded for oral use. My vet told me if it is the IV compound it will NOT work orally.
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mollibtexan
Reg. Jan 2007
Posted 2016-05-10 10:39 PM
Subject: RE: Guanabenz



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bbm85 - 2016-05-10 3:48 PM

A little late to join the conversation on this thread but what is the difference between Guanabenz and Chlorpromazine ?

Guanabenz controls heart rate. Chloropromazine controls anxiety.
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uno-dos-tres!
Reg. Jul 2004
Posted 2016-05-11 1:01 AM
Subject: RE: Guanabenz


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mollibtexan - 2016-05-10 10:39 PM
bbm85 - 2016-05-10 3:48 PM A little late to join the conversation on this thread but what is the difference between Guanabenz and Chlorpromazine ?
Guanabenz controls heart rate. Chloropromazine controls anxiety.

guanabenz is used to control HTN (high blood pressure) and HR (heart rate) it depresses the CNS at the cortical level (think core and not periphery)  

your onset is pretty rapid about an hour in horses and for me it stays around up to 4 hours 

you don't want to use this and propranolol together! 

You get depression/sedation and control of vaso tone thru this med

chloropromazine is an old psych med that restores the brains natural chemicals, it works on the  CNS at all levels has been used to treat anxiety in acute cases for a long time. 

for horses you need to be careful in using it with lasix and never with propranolol. Lasix and chlor can cause significant hypotension. Chlor and propranolol (or any other betablocker can be fatal). 

Like Molli stated earlier in a roundabout way. Those that train have pretty good knowledge on these meds but every so often you have to change timing and dose on a horse to get a therapuetic effect. I had a wonderful psych doc sit with me one night in the ER years ago explain to me the need to slowly ramp certian drugs in psych pt's and he thought that would be true in my horses. 
Try to get with a doc that enjoys pharmacology and will look at the whole horse and his problems. You want to be certian that your not going to get into trouble by using concurrent meds. 
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MS2011
Reg. Mar 2005
Posted 2016-05-11 9:43 AM
Subject: RE: Guanabenz



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uno-dos-tres! - 2016-05-11 1:01 AM
mollibtexan - 2016-05-10 10:39 PM
bbm85 - 2016-05-10 3:48 PM A little late to join the conversation on this thread but what is the difference between Guanabenz and Chlorpromazine ?
Guanabenz controls heart rate. Chloropromazine controls anxiety.
guanabenz is used to control HTN (high blood pressure) and HR (heart rate) it depresses the CNS at the cortical level (think core and not periphery)  



your onset is pretty rapid about an hour in horses and for me it stays around up to 4 hours 



you don't want to use this and propranolol together! 



You get depression/sedation and control of vaso tone thru this med



chloropromazine is an old psych med that restores the brains natural chemicals, it works on the  CNS at all levels has been used to treat anxiety in acute cases for a long time. 



for horses you need to be careful in using it with lasix and never with propranolol. Lasix and chlor can cause significant hypotension. Chlor and propranolol (or any other betablocker can be fatal). 



Like Molli stated earlier in a roundabout way. Those that train have pretty good knowledge on these meds but every so often you have to change timing and dose on a horse to get a therapuetic effect. I had a wonderful psych doc sit with me one night in the ER years ago explain to me the need to slowly ramp certian drugs in psych pt's and he thought that would be true in my horses. 

Try to get with a doc that enjoys pharmacology and will look at the whole horse and his problems. You want to be certian that your not going to get into trouble by using concurrent meds. 

Thank you and mollibtexan for the explantions.
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bbm85
Reg. Apr 2016
Posted 2016-05-11 10:22 AM
Subject: RE: Guanabenz


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Thank you for the explanations !
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goldcard
Reg. Sep 2006
Posted 2016-05-11 1:30 PM
Subject: RE: Guanabenz



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Guanabenz is a class 3 drug and not legal in the WPRA. It's not FDA approved for use in horses. Just know that if you are entered in a PRCA / WPRA rodeo there could be drug testing and if you happen to be one chosen in the random draw you will be fined for it's use.
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ntxray
Reg. Jul 2009
Posted 2022-02-27 6:44 PM
Subject: RE: Guanabenz


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Does GuanaBenz have a Lasix effect? I tried it on two of my horses today, and they seem like they are both colicky now

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CanCan
Reg. May 2004
Posted 2022-02-27 7:30 PM
Subject: RE: Guanabenz


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ntxray - 2022-02-27 6:44 PM


Does GuanaBenz have a Lasix effect? I tried it on two of my horses today, and they seem like they are both colicky now


I guess it's possible. Did you give it as directed by vet?

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