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Guanabenz

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mollibtexan
Reg. Jan 2007
Posted 2016-04-06 3:18 PM
Subject: RE: Guanabenz



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30-45 min out
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Shorty 2
Reg. Apr 2005
Posted 2016-04-06 3:22 PM
Subject: RE: Guanabenz


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mollibtexan - 2016-04-06 1:18 PM

30-45 min out

Just to clarify for me, you're talking about the oral dosing, correct? Not familiar with the oral, since had only heard about the IV Guanabenz.
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soonergirl98
Reg. Oct 2009
Posted 2016-04-06 4:36 PM
Subject: RE: Guanabenz



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I recently had a discussion with a vet regarding whether to use Guanabenz or Sedivet for a horse that has serious anxiety problems from being run while hurt by a previous owner. The vet said Guanabenz actually lowers blood pressure and some will use it in place of low doses of lasix and Sedivet was designed just for anxiety and will not lower BP.
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mollibtexan
Reg. Jan 2007
Posted 2016-04-06 9:39 PM
Subject: RE: Guanabenz



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Shorty 2 - 2016-04-06 3:22 PM

mollibtexan - 2016-04-06 1:18 PM

30-45 min out

Just to clarify for me, you're talking about the oral dosing, correct? Not familiar with the oral, since had only heard about the IV Guanabenz.

I'm not exactly sure about that. I always do IV when I use it. If you do oral you might do further out. Try this at home first to see the effects you get.
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mollibtexan
Reg. Jan 2007
Posted 2016-04-06 9:44 PM
Subject: RE: Guanabenz



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Setivet was not designed for anxiety although it is used for such in low doses. Acepromazine is designed for anxiety.
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bbm85
Reg. Apr 2016
Posted 2016-05-10 3:48 PM
Subject: RE: Guanabenz


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A little late to join the conversation on this thread but what is the difference between Guanabenz and Chlorpromazine ?
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barrelbasher
Reg. Apr 2007
Posted 2016-05-10 8:13 PM
Subject: RE: Guanabenz



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Make sure if you plan to use guanabenz orally that it is compounded for oral use. My vet told me if it is the IV compound it will NOT work orally.
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mollibtexan
Reg. Jan 2007
Posted 2016-05-10 10:39 PM
Subject: RE: Guanabenz



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bbm85 - 2016-05-10 3:48 PM

A little late to join the conversation on this thread but what is the difference between Guanabenz and Chlorpromazine ?

Guanabenz controls heart rate. Chloropromazine controls anxiety.
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uno-dos-tres!
Reg. Jul 2004
Posted 2016-05-11 1:01 AM
Subject: RE: Guanabenz


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mollibtexan - 2016-05-10 10:39 PM
bbm85 - 2016-05-10 3:48 PM A little late to join the conversation on this thread but what is the difference between Guanabenz and Chlorpromazine ?
Guanabenz controls heart rate. Chloropromazine controls anxiety.

guanabenz is used to control HTN (high blood pressure) and HR (heart rate) it depresses the CNS at the cortical level (think core and not periphery)  

your onset is pretty rapid about an hour in horses and for me it stays around up to 4 hours 

you don't want to use this and propranolol together! 

You get depression/sedation and control of vaso tone thru this med

chloropromazine is an old psych med that restores the brains natural chemicals, it works on the  CNS at all levels has been used to treat anxiety in acute cases for a long time. 

for horses you need to be careful in using it with lasix and never with propranolol. Lasix and chlor can cause significant hypotension. Chlor and propranolol (or any other betablocker can be fatal). 

Like Molli stated earlier in a roundabout way. Those that train have pretty good knowledge on these meds but every so often you have to change timing and dose on a horse to get a therapuetic effect. I had a wonderful psych doc sit with me one night in the ER years ago explain to me the need to slowly ramp certian drugs in psych pt's and he thought that would be true in my horses. 
Try to get with a doc that enjoys pharmacology and will look at the whole horse and his problems. You want to be certian that your not going to get into trouble by using concurrent meds. 
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MS2011
Reg. Mar 2005
Posted 2016-05-11 9:43 AM
Subject: RE: Guanabenz



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uno-dos-tres! - 2016-05-11 1:01 AM
mollibtexan - 2016-05-10 10:39 PM
bbm85 - 2016-05-10 3:48 PM A little late to join the conversation on this thread but what is the difference between Guanabenz and Chlorpromazine ?
Guanabenz controls heart rate. Chloropromazine controls anxiety.
guanabenz is used to control HTN (high blood pressure) and HR (heart rate) it depresses the CNS at the cortical level (think core and not periphery)  



your onset is pretty rapid about an hour in horses and for me it stays around up to 4 hours 



you don't want to use this and propranolol together! 



You get depression/sedation and control of vaso tone thru this med



chloropromazine is an old psych med that restores the brains natural chemicals, it works on the  CNS at all levels has been used to treat anxiety in acute cases for a long time. 



for horses you need to be careful in using it with lasix and never with propranolol. Lasix and chlor can cause significant hypotension. Chlor and propranolol (or any other betablocker can be fatal). 



Like Molli stated earlier in a roundabout way. Those that train have pretty good knowledge on these meds but every so often you have to change timing and dose on a horse to get a therapuetic effect. I had a wonderful psych doc sit with me one night in the ER years ago explain to me the need to slowly ramp certian drugs in psych pt's and he thought that would be true in my horses. 

Try to get with a doc that enjoys pharmacology and will look at the whole horse and his problems. You want to be certian that your not going to get into trouble by using concurrent meds. 

Thank you and mollibtexan for the explantions.
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bbm85
Reg. Apr 2016
Posted 2016-05-11 10:22 AM
Subject: RE: Guanabenz


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Thank you for the explanations !
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goldcard
Reg. Sep 2006
Posted 2016-05-11 1:30 PM
Subject: RE: Guanabenz



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Guanabenz is a class 3 drug and not legal in the WPRA. It's not FDA approved for use in horses. Just know that if you are entered in a PRCA / WPRA rodeo there could be drug testing and if you happen to be one chosen in the random draw you will be fined for it's use.
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ntxray
Reg. Jul 2009
Posted 2022-02-27 6:44 PM
Subject: RE: Guanabenz


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Does GuanaBenz have a Lasix effect? I tried it on two of my horses today, and they seem like they are both colicky now

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CanCan
Reg. May 2004
Posted 2022-02-27 7:30 PM
Subject: RE: Guanabenz


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ntxray - 2022-02-27 6:44 PM


Does GuanaBenz have a Lasix effect? I tried it on two of my horses today, and they seem like they are both colicky now


I guess it's possible. Did you give it as directed by vet?

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