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Location: Texas | 30-45 min out |
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Elite Veteran
Posts: 672
Location: On the rodeo trail with Brenda, Dora, Zeva, | mollibtexan - 2016-04-06 1:18 PM
30-45 min out
Just to clarify for me, you're talking about the oral dosing, correct? Not familiar with the oral, since had only heard about the IV Guanabenz. |
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 Expert
Posts: 2013
Location: Piedmont, OK | I recently had a discussion with a vet regarding whether to use Guanabenz or Sedivet for a horse that has serious anxiety problems from being run while hurt by a previous owner. The vet said Guanabenz actually lowers blood pressure and some will use it in place of low doses of lasix and Sedivet was designed just for anxiety and will not lower BP. |
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Expert
Posts: 1526
Location: Texas | Shorty 2 - 2016-04-06 3:22 PM
mollibtexan - 2016-04-06 1:18 PM
30-45 min out
Just to clarify for me, you're talking about the oral dosing, correct? Not familiar with the oral, since had only heard about the IV Guanabenz.
I'm not exactly sure about that. I always do IV when I use it. If you do oral you might do further out. Try this at home first to see the effects you get. |
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Expert
Posts: 1526
Location: Texas | Setivet was not designed for anxiety although it is used for such in low doses. Acepromazine is designed for anxiety. |
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boon
Posts: 4
| A little late to join the conversation on this thread but what is the difference between Guanabenz and Chlorpromazine ? |
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 Expert
Posts: 1440
Location: Texas | Make sure if you plan to use guanabenz orally that it is compounded for oral use. My vet told me if it is the IV compound it will NOT work orally. |
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Expert
Posts: 1526
Location: Texas | bbm85 - 2016-05-10 3:48 PM
A little late to join the conversation on this thread but what is the difference between Guanabenz and Chlorpromazine ?
Guanabenz controls heart rate. Chloropromazine controls anxiety. |
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Expert
Posts: 4766
Location: Bandera, TX | mollibtexan - 2016-05-10 10:39 PM bbm85 - 2016-05-10 3:48 PM A little late to join the conversation on this thread but what is the difference between Guanabenz and Chlorpromazine ? Guanabenz controls heart rate. Chloropromazine controls anxiety.
guanabenz is used to control HTN (high blood pressure) and HR (heart rate) it depresses the CNS at the cortical level (think core and not periphery)
your onset is pretty rapid about an hour in horses and for me it stays around up to 4 hours
you don't want to use this and propranolol together!
You get depression/sedation and control of vaso tone thru this med
chloropromazine is an old psych med that restores the brains natural chemicals, it works on the CNS at all levels has been used to treat anxiety in acute cases for a long time.
for horses you need to be careful in using it with lasix and never with propranolol. Lasix and chlor can cause significant hypotension. Chlor and propranolol (or any other betablocker can be fatal).
Like Molli stated earlier in a roundabout way. Those that train have pretty good knowledge on these meds but every so often you have to change timing and dose on a horse to get a therapuetic effect. I had a wonderful psych doc sit with me one night in the ER years ago explain to me the need to slowly ramp certian drugs in psych pt's and he thought that would be true in my horses.
Try to get with a doc that enjoys pharmacology and will look at the whole horse and his problems. You want to be certian that your not going to get into trouble by using concurrent meds. |
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 Own It and Move On
Location: The edge of no where | uno-dos-tres! - 2016-05-11 1:01 AM mollibtexan - 2016-05-10 10:39 PM bbm85 - 2016-05-10 3:48 PM A little late to join the conversation on this thread but what is the difference between Guanabenz and Chlorpromazine ? Guanabenz controls heart rate. Chloropromazine controls anxiety.
your onset is pretty rapid about an hour in horses and for me it stays around up to 4 hours
you don't want to use this and propranolol together!
You get depression/sedation and control of vaso tone thru this med
chloropromazine is an old psych med that restores the brains natural chemicals, it works on the CNS at all levels has been used to treat anxiety in acute cases for a long time.
for horses you need to be careful in using it with lasix and never with propranolol. Lasix and chlor can cause significant hypotension. Chlor and propranolol (or any other betablocker can be fatal).
Like Molli stated earlier in a roundabout way. Those that train have pretty good knowledge on these meds but every so often you have to change timing and dose on a horse to get a therapuetic effect. I had a wonderful psych doc sit with me one night in the ER years ago explain to me the need to slowly ramp certian drugs in psych pt's and he thought that would be true in my horses.
Try to get with a doc that enjoys pharmacology and will look at the whole horse and his problems. You want to be certian that your not going to get into trouble by using concurrent meds.
Thank you and mollibtexan for the explantions. |
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boon
Posts: 4
| Thank you for the explanations ! |
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 Elite Veteran
Posts: 832
Location: Kansas (but Great Lakes member since 1978) | Guanabenz is a class 3 drug and not legal in the WPRA. It's not FDA approved for use in horses. Just know that if you are entered in a PRCA / WPRA rodeo there could be drug testing and if you happen to be one chosen in the random draw you will be fined for it's use.
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Member
Posts: 11
| Does GuanaBenz have a Lasix effect? I tried it on two of my horses today, and they seem like they are both colicky now |
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  Keeper of the King Snake
Posts: 7461
Location: Dubach, LA | ntxray - 2022-02-27 6:44 PM
Does GuanaBenz have a Lasix effect? I tried it on two of my horses today, and they seem like they are both colicky now
I guess it's possible. Did you give it as directed by vet? |
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