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Blessed 
   
Location: Here | okay I have a question.
We all know right? that our own DNA can mutate. So just because a stallion isn't positive at this point what is to say his Dna for this stuff won't mutate later? Just concerns me the more I read about factors that can cause DNA to mutate. Will this really be a sound test? I have done a lot of reading on DNA mutations and What guarantee do we have that this stuff is really being transferred? I quess I am questioning the PSSM1 stuff because what I read is it is clearly a gene mutation |
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 Swiffer PIcker Upper
Posts: 4015
Location: Four Corners Colorado | SG. - 2014-02-20 11:30 AM okay I have a question.
We all know right? that our own DNA can mutate. So just because a stallion isn't positive at this point what is to say his Dna for this stuff won't mutate later? Just concerns me the more I read about factors that can cause DNA to mutate. Will this really be a sound test? I have done a lot of reading on DNA mutations and What guarantee do we have that this stuff is really being transferred? I quess I am questioning the PSSM1 stuff because what I read is it is clearly a gene mutation
Kind of like Epigenetics? |
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Blessed
Location: Here | equussynergy - 2014-02-20 12:51 PM SG. - 2014-02-20 11:30 AM okay I have a question.
We all know right? that our own DNA can mutate. So just because a stallion isn't positive at this point what is to say his Dna for this stuff won't mutate later? Just concerns me the more I read about factors that can cause DNA to mutate. Will this really be a sound test? I have done a lot of reading on DNA mutations and What guarantee do we have that this stuff is really being transferred? I quess I am questioning the PSSM1 stuff because what I read is it is clearly a gene mutation Kind of like Epigenetics?
No... Our own Dna mutates because of different factors. Food environment etc |
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 Undercover Amish Mafia Member
Posts: 9992
Location: Kansas | NJJ - 2014-02-13 8:46 AM BARRELHORSE USA - 2014-02-13 1:54 Of course everyone has seen the one photograph of a bad case of sun/rain scald on a Mississippi or Louisiana horse provided by the dimwit that invented the HERDA DNA nonsense ... and again it traces back to KING P234 THRU POCO BUENO
What you need to be doing is getting rid of all of your barn and house cats that are the principal carriers of EPM ... NOT THE POSSUM ... who carries an entirely different strain that does not affect horses or other livestock ... . I rarely EVER post on these types of threads but I just have to ask you ....DO YOU SMOKE DOPE????
Your dissertation was filled with so much mis-information and stupidity that I find myself having address a couple of issues.........
ONE: HERDA is NOT a made-up disease...I have personally seen a horse (that had to be put down) who had this disease and yes, it was a fourth generation Poco Bueno and NO>>>>It was NOT rain scald..........Have YOU ever actually seen a horse diagnosed with HERDA???? "Rain rot" certainly does NOT make the skin pull away from the underlying muscles in large sections.....and you are an idiot if you think it does......
TWO: Cats CAN be an "intermediate" host of EPM....they CAN carry the disease but can NOT reproduce the protozia. They CAN spread the disease to oppossum's (through the ingestion of a cat)...ONLY opposum's pass the protozoia on to the horse through their feces in feed or water.......
O shoot! This seriously made me crack up! O goodness Norma, thanks for the laugh LOL |
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  Champ
Posts: 19623
Location: Peg-Leg Julia Grimm | SG. - 2014-02-20 10:30 AM okay I have a question.
We all know right? that our own DNA can mutate. So just because a stallion isn't positive at this point what is to say his Dna for this stuff won't mutate later? Just concerns me the more I read about factors that can cause DNA to mutate. Will this really be a sound test? I have done a lot of reading on DNA mutations and What guarantee do we have that this stuff is really being transferred? I quess I am questioning the PSSM1 stuff because what I read is it is clearly a gene mutation
Considering these defects have been around for 1000's of years, I wouldn't worry too much about new mutations. They might happen in the future but there's nothing we can do about it. The mutation may be a good mutation that improves horses who have it (think X Factor Heartlines) or it may be an undesireable mutation such as HYPP.
I just read something today about PSSM1 possibly being a GOOD mutation when horses didn't get fed like they do today. i.e. grain. They got worked harder and had to rough it on low nutrition diets. Now of course we feed differently than horses evolved to eat, so we notice these problems more and the same mutation that used to be good is now bad.  |
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Blessed
Location: Here | OregonBR - 2014-02-20 5:36 PM SG. - 2014-02-20 10:30 AM okay I have a question.
We all know right? that our own DNA can mutate. So just because a stallion isn't positive at this point what is to say his Dna for this stuff won't mutate later? Just concerns me the more I read about factors that can cause DNA to mutate. Will this really be a sound test? I have done a lot of reading on DNA mutations and What guarantee do we have that this stuff is really being transferred? I quess I am questioning the PSSM1 stuff because what I read is it is clearly a gene mutation Considering these defects have been around for 1000's of years, I wouldn't worry too much about new mutations. They might happen in the future but there's nothing we can do about it. The mutation may be a good mutation that improves horses who have it (think X Factor Heartlines) or it may be an undesireable mutation such as HYPP.
I just read something today about PSSM1 possibly being a GOOD mutation when horses didn't get fed like they do today. i.e. grain. They got worked harder and had to rough it on low nutrition diets. Now of course we feed differently than horses evolved to eat, so we notice these problems more and the same mutation that used to be good is now bad.
THANK YOU!!! |
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 "Drank the Kool Aid"
Posts: 5496
Location: Iowa, LA | OregonBR - 2014-02-20 5:36 PM
SG. - 2014-02-20 10:30 AM okay I have a question.
We all know right? that our own DNA can mutate. So just because a stallion isn't positive at this point what is to say his Dna for this stuff won't mutate later? Just concerns me the more I read about factors that can cause DNA to mutate. Will this really be a sound test? I have done a lot of reading on DNA mutations and What guarantee do we have that this stuff is really being transferred? I quess I am questioning the PSSM1 stuff because what I read is it is clearly a gene mutationÂ
Considering these defects have been around for 1000's of years, I wouldn't worry too much about new mutations. They might happen in the future but there's nothing we can do about it. The mutation may be a good mutation that improves horses who have it (think X Factor Heartlines) or it may be an undesireable mutation such as HYPP. Â
I just read something today about PSSM1 possibly being a GOOD mutation when horses didn't get fed like they do today. i.e. grain. They got worked harder and had to rough it on low nutrition diets. Now of course we feed differently than horses evolved to eat, so we notice these problems more and the same mutation that used to be good is now bad.  Â
Exactly! When horses were worked....actually had a job....then it could be a good thing to have excess energy (glycogen) storage and an actual benefit. But today, we are using them as "hobbies" and feeding lots of concentrates/high starch diets. |
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"Drank the Kool Aid"
Posts: 5496
Location: Iowa, LA | OregonBR - 2014-02-20 5:36 PM
SG. - 2014-02-20 10:30 AM okay I have a question.
We all know right? that our own DNA can mutate. So just because a stallion isn't positive at this point what is to say his Dna for this stuff won't mutate later? Just concerns me the more I read about factors that can cause DNA to mutate. Will this really be a sound test? I have done a lot of reading on DNA mutations and What guarantee do we have that this stuff is really being transferred? I quess I am questioning the PSSM1 stuff because what I read is it is clearly a gene mutationÂ
Considering these defects have been around for 1000's of years, I wouldn't worry too much about new mutations. They might happen in the future but there's nothing we can do about it. The mutation may be a good mutation that improves horses who have it (think X Factor Heartlines) or it may be an undesireable mutation such as HYPP. Â
I just read something today about PSSM1 possibly being a GOOD mutation when horses didn't get fed like they do today. i.e. grain. They got worked harder and had to rough it on low nutrition diets. Now of course we feed differently than horses evolved to eat, so we notice these problems more and the same mutation that used to be good is now bad.  Â
Exactly! When horses were worked....actually had a job....then it could be a good thing to have excess energy (glycogen) storage and an actual benefit. But today, we are using them as "hobbies" and feeding lots of concentrates/high starch diets. |
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 The Color Specialist
Posts: 7530
Location: Washington. (The DRY side.) | I wonder if the above is why some folks have "issues" with their horses, yet others say they are nonsymptomatic?? Maybe the ones that aren't seeing a problem are being used, and/or not being "fed up" |
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Blessed
Location: Here | RacingQH - 2014-02-20 9:56 PM
I wonder if the above is why some folks have "issues" with their horses, yet others say they are nonsymptomatic?? Maybe the ones that aren't seeing a problem are being used, and/or not being "fed up"
Exactly! and makes me wonder about all this genetic testing. Where is it going to end? |
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"Drank the Kool Aid"
Posts: 5496
Location: Iowa, LA | RacingQH - 2014-02-20 9:56 PM
I wonder if the above is why some folks have "issues" with their horses, yet others say they are nonsymptomatic?? Maybe the ones that aren't seeing a problem are being used, and/or not being "fed up"
I think it has a lot to do with it! Also, these symptoms can be so easily confused with other issues, such as loose/sticky stifles, hock problems, saddle fit, ulcers, etc. And if you just saw my two out in the pasture, you'd never know anything was wrong. Neither of mine tie up. |
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