Toltrazuril for EPM

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Toltrazuril for EPM Moderators: luluwhit, gotothewhip, cindyt, crossspur, ForumAdmin Jump to page :	Last activity 2015-10-09 9:05 PM 6 replies, 3765 views View previous thread :: View next thread
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Alittlelost Reg. May 2011	Posted 2015-10-08 1:32 PM Subject: Toltrazuril for EPM
Member Posts: 38	How much toltrazuril 5% do you give to treat for EPM ? Thank you
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Warriors Mom Reg. Mar 2015	Posted 2015-10-08 4:56 PM Subject: RE: Toltrazuril for EPM
Veteran Posts: 274	quine protozoal myeloencephalitis (EPM) is a serious disorder of the nervous system of horses caused by Sarcocystis neurona. Recently, toltrazuril has begun to be used for treatment of EPM. The purpose of this study was to evaluate the potential toxicity of toltrazuril in horses when administered at a dose of 50 mg/kg for 10 days. Five horses were given 50 mg/kg of toltrazuril once daily for 10 days by nasogastric tube. Complete blood cell counts, serum chemistry values, and coagulation panels were evaluated before and after treatment; then a full postmortem examination was completed on day 11. Results of the study show that only mild clinical signs (i.e., anorexia, weight loss, and colic in one of the five horses) were observed after treatment. Minimal changes were noted in the serum chemistry analysis (i.e., increased bilirubin and serum protein, mildly increased hematocrit and hemoglobin concentration, and mildly increased albumin). Renal medullary congestion was noted on gross postmortem examination; however, no microscopic changes due to compound administration were noted in the kidneys or other tissue. Results of this study suggest that administration of toltrazuril at 50 mg/kg (5x to 10x anticipated clinical dosage) for 10 days resulted in only mild clinical abnormalities.
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livinonlove&horses Reg. Jun 2008	Posted 2015-10-08 8:52 PM Subject: RE: Toltrazuril for EPM
Ms. Poutability Posts: 2362 Location: In my own world	I can't remember how much I gave. It was a small syringe like 10cc. Gave it every day for 30 days. By week 2 my mare showed great improvement. She wasn't hugely symptomatic but was weak enough she could not trot in a small circle without stumbling
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Alittlelost Reg. May 2011	Posted 2015-10-08 11:18 PM Subject: RE: Toltrazuril for EPM
Member Posts: 38	Thank you for the great info . Lots of people we know love this stuff , but they all have told different amouts to give and time to give . Hope to get more replies ! Thanks
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lopnaround Reg. Mar 2010	Posted 2015-10-09 1:17 PM Subject: RE: Toltrazuril for EPM
Expert Posts: 1599	My bottle says intial dose 35cc, 8cc daily after.
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Alittlelost Reg. May 2011	Posted 2015-10-09 1:22 PM Subject: RE: Toltrazuril for EPM
Member Posts: 38	Thank you that's sound about right . How long did you do 8cc ? Did you have good results ? Thanks
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livinonlove&horses Reg. Jun 2008	Posted 2015-10-09 9:05 PM Subject: RE: Toltrazuril for EPM
Ms. Poutability Posts: 2362 Location: In my own world	Alittlelost - 2015-10-09 1:22 PM Thank you that's sound about right . How long did you do 8cc ? Did you have good results ? Thanks I wanted to also tell you that I used the medicine you are talking about for a month. It was a compounded formula. I used it because my horse did not show any major signs. Like not walking drunk. After we saw that it was working I did another month of meds but I used the name brand stuff, Protazil? I think is the name.
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