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 Go For It!
   
Location: Texas | Well I can tell you this... I had a mare OTT that had terrible ulcers (years ago). I bought Prilosec OTC and drenched her 8 pills 1 X daily and her ulcers cleared up. I let the pills soak and made them into a paste. It worked and was WAY cheaper than the horse version.
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Extreme Veteran
Posts: 330
| ACEINTHEHOLE - 2014-05-29 2:23 PM
Just some more FYI on different types of acid medications:
Omeprazole blocks for 12 hr a day. Ranitidine/cimitadine only block partially and only for about 4-5 hrs at a time. Nutricueticals and antacids only act on the acid in the stomach - so only about 30 min to 1 hr duration. Horses don't have a gall bladder so they produce acid all the time. We can get away with Tums etc because we only produce acid when we eat.
Omeprazole - 24 hours
Ranitidine - 8 hours |
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Extreme Veteran
Posts: 330
| grinandbareit - 2014-05-30 1:12 AM
Well I can tell you this... I had a mare OTT that had terrible ulcers (years ago). I bought Prilosec OTC and drenched her 8 pills 1 X daily and her ulcers cleared up. I let the pills soak and made them into a paste. It worked and was WAY cheaper than the horse version.
And of course you have before and after scopes to substantiate your proof? |
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 Tough Patooty
Posts: 2615
Location: Sperry, OK | SuckerForHorses - 2014-05-30 7:07 AM ACEINTHEHOLE - 2014-05-29 2:23 PM Just some more FYI on different types of acid medications:
Omeprazole blocks for 12 hr a day. Ranitidine/cimitadine only block partially and only for about 4-5 hrs at a time. Nutricueticals and antacids only act on the acid in the stomach - so only about 30 min to 1 hr duration. Horses don't have a gall bladder so they produce acid all the time. We can get away with Tums etc because we only produce acid when we eat. Omeprazole - 24 hours Ranitidine - 8 hours
Well my info comes straight from Merial, as I have a friend that is a rep for them. This information is the information learned straight from their studies. |
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Extreme Veteran
Posts: 330
| Well then perhaps you should ask your friend why the GastroGard INSTRUCTIONS say to dose once per day, instead of every 12 hours?
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 Pork Fat is my Favorite
Posts: 3791
Location: The Oklahoma plains. | SuckerForHorses - 2014-05-30 7:07 AM grinandbareit - 2014-05-30 1:12 AM Well I can tell you this... I had a mare OTT that had terrible ulcers (years ago). I bought Prilosec OTC and drenched her 8 pills 1 X daily and her ulcers cleared up. I let the pills soak and made them into a paste. It worked and was WAY cheaper than the horse version. And of course you have before and after scopes to substantiate your proof?
My question too |
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 Expert
Posts: 5293
| All this aside, I think its funny that you can give Ulcerguard OTC for half a tube, but need vets permission to give whole tube. lol Come on, it all needs to be OTC. |
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Tough Patooty
Posts: 2615
Location: Sperry, OK | SuckerForHorses - 2014-05-30 8:59 AM Well then perhaps you should ask your friend why the GastroGard INSTRUCTIONS say to dose once per day, instead of every 12 hours?
Because you only want to shut the pumps off enough to reduce acid production to a level that will not create ulcers (allow current ulcers to heal)... you still have to have enough acid to digest food. If you shut them off completely you will end up with colic issues. |
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Extreme Veteran
Posts: 330
| ACEINTHEHOLE - 2014-05-30 11:07 AM
SuckerForHorses - 2014-05-30 8:59 AM Well then perhaps you should ask your friend why the GastroGard INSTRUCTIONS say to dose once per day, instead of every 12 hours?
Because you only want to shut the pumps off enough to reduce acid production to a level that will not create ulcers (allow current ulcers to heal)... you still have to have enough acid to digest food. If you shut them off completely you will end up with colic issues.
Show me the citation for this information.
The AMOUNT of omeprazole given is what determines how many pumps get shut down.
The amount in a tube of GastroGard is enough to shut X number down for 24 HOURS. That's why it's a 24-hour dosing regimen.
Edited by SuckerForHorses 2014-05-30 10:27 AM
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Extreme Veteran
Posts: 330
| FLITASTIC - 2014-05-30 11:04 AM
All this aside, I think its funny that you can give Ulcerguard OTC for half a tube, but need vets permission to give whole tube. lol Come on, it all needs to be OTC.
Just buy UlcerGard, and give a full tube. No script required.
There is the same amount of omeprazole in a tube of UlcerGard as there is in GastroGard.
Its the same idea as for human ibuprofen - you can only get 800 mg tablets with a prescription but you can buy OTC a bottle of it, and take 4, 200 mg tablets on your own. |
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Extreme Veteran
Posts: 330
| UlcerGard is cheaper per tube also, so I'm not really sure why anybody even purchases GastroGard tubes! LOL! |
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Tough Patooty
Posts: 2615
Location: Sperry, OK | SuckerForHorses - 2014-05-30 10:22 AM ACEINTHEHOLE - 2014-05-30 11:07 AM SuckerForHorses - 2014-05-30 8:59 AM Well then perhaps you should ask your friend why the GastroGard INSTRUCTIONS say to dose once per day, instead of every 12 hours? Because you only want to shut the pumps off enough to reduce acid production to a level that will not create ulcers (allow current ulcers to heal)... you still have to have enough acid to digest food. If you shut them off completely you will end up with colic issues. Show me the citation for this information. The AMOUNT of omeprazole given is what determines how many pumps get shut down. The amount in a tube of GastroGard is enough to shut X number down for 24 HOURS. That's why it's a 24-hour dosing regimen.
I guess since you are the one that works for the company that did the studies and has access to all the information for specifics on how the product works, there is no reason for me to provide you with anything.. I am sure you already have it. On the same note, why don't you provide me with citations detailing that Omeprazole works for 24 hours in the horse NOT human as you have stated, and with the information as to why it is labeled for 24 hr dosing and not 12, as I am certain you have that as well. I am sure the manufacturer of the product knows how the products works on HORSES better than you do, and all my information is straight from them. |
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Extreme Veteran
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| "Pharmacodynamics: In a study of pharmacodynamic effects using horses with gastric cannulae, secretion of gastric acid was inhibited in horses given 4 mg omeprazole/kg/day. After the expected maximum suppression of gastric acid secretion was reached (5 days), the actual secretion of gastric acid was reduced by 99%, 95% and 90% at 8, 16, and 24 hours, respectively."
http://www.drugs.com/pro/gastrogard.html
Gastric acid production was still reduced by 90% after 24 hours...that's why it's not needed every 12. After 24 hours, still 90% of the acid is not being produced. So yes, it does do its intended job (to reduce acid production) for 24 hours. In fact, after 24 hours, it's hardly begun to wear off/stop working as intended.
Efficacy of omeprazole paste for prevention of gastric ulcers in horses in race training...
CONCLUSIONS AND CLINICAL RELEVANCE; Results indicated that omeprazole administered at a dosage of 1 mg/kg, PO, every 24 hours for 28 days was effective for prevention of gastric ulcers in horses starting race training.
http://www.ncbi.nlm.nih.gov/pubmed/15906568
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