|
|
Expert
Posts: 1611
  
| I've ordered this before made by Hytryl its off label use. http://www.allvetsupply.com/hy5x6mlvi.html
It works the same as legend as far as giving before a big show. If I had the money to give it every time through the gate I would but I must be economical.
I'm not a pentosan fan although I have used it.
Does paying more for the higher price of legend have any long term benefits? I've used off labels and had the same results as the real thing....wondering if there are any long term benefits to the higher molecular weight HA? |
|
| |
|
 Expert
Posts: 2604
Location: Texas | Can't comment on your question.
But why are you not a fan of Pentosan? I am considering it & trying to find out more info. Thanks |
|
| |
|
 Expert
Posts: 5293
 
| astreakinchic - 2015-04-06 8:31 AM
I've ordered this before made by Hytryl its off label use. http://www.allvetsupply.com/hy5x6mlvi.html
It works the same as legend as far as giving before a big show. If I had the money to give it every time through the gate I would but I must be economical.
I'm not a pentosan fan although I have used it.
Does paying more for the higher price of legend have any long term benefits? I've used off labels and had the same results as the real thing....wondering if there are any long term benefits to the higher molecular weight HA?
I have used Hytryl and Legend interchangeably. And not all HA's are the same. THey differ in their Dalton ( Size of molecule) rating. THis affects how they are absorbed/used. This is the problem with feed throughs. The size of molecule it takes to make it past the stomach is to big to be absorbed in the GI tract. This is why Lubrisyn claims theirs is absorbed before it even gets to the stomach. Another option is Nex HA. Its identical to Legend and is APPROVED by the FDA for IV use. Just like Legend.
As for Long term? All IV HA products last in a horse's system about 72 hours and are gone, they are not designed to have long term effects unless injected directly into the joint.
Edited by FLITASTIC 2015-04-10 10:27 AM
|
|
| |
|
Expert
Posts: 1611
| TBone - 2015-04-10 10:53 AM Can't comment on your question.
But why are you not a fan of Pentosan? I am considering it & trying to find out more info. Thanks
PENTOSAN
Pentosan Polysulfate is a drug to treat osteoarthritis in horses. It has been used
in Australia and Europe for 30 years as an anti arthritic drug in sport horses. Originally used in humans to help prevent blood clots, there are no documented increases in problems associated with exercised induced pulmonary hemorrhage (bleeding after racing) with horses on the drug.
Pentosan has no analgesic or pain relieving effects. It works in the joint improving the health of the joint in 4 ways.
1. It stimulates the production of proteoglycans which are incorporated in the cartilage that makes up the joint’s weight bearing surface.
Athletic use over time causes joint wear and tear and it is the loss of proteoglycans from the cartilage matrix that weakens the cartilage causing lameness and arthritis. The drug’s ability to replace proteoglycans in the cartilage halts the progression of arthritis.
2. It stimulates the synovial cells on the joint capsule to produce hyalouronic acid. This improves the thickness and volume of the joint fluid which lubricates the joint preventing further damage to the joint cartilage.
3. It blocks and decreases the inflammatory compounds in the joint which also cause degradation of the cartilage
4. It removes fibrin clots from blood vessels allowing better blood flow in the joint.
Pentosancanbegivenorally,inthemuscle,IV,orinthejoint. Astudyshowedthat the drug did go to the joints with a significant concentration in the joint fluid from IM injection of Pentosan Polysulfate. Colorado State did an osteoarthritis study which did not show a difference in lameness between the treated and nontreated horses but there was a difference in the cartilage microscopically.
Pentosan is generally given IM once a week for 4-5 weeks and then once a month.
I highlighted the above because to my knowledge nothing as been published on this but I am still leary. |
|
| |
|
Rad Dork
Posts: 5218
Location: Oklahoma | FLITASTIC - 2015-04-10 10:25 AM astreakinchic - 2015-04-06 8:31 AM I've ordered this before made by Hytryl its off label use. http://www.allvetsupply.com/hy5x6mlvi.html It works the same as legend as far as giving before a big show. If I had the money to give it every time through the gate I would but I must be economical. I'm not a pentosan fan although I have used it. Does paying more for the higher price of legend have any long term benefits? I've used off labels and had the same results as the real thing....wondering if there are any long term benefits to the higher molecular weight HA? I have used Hytryl and Legend interchangeably. And not all HA's are the same. THey differ in their Dalton ( Size of molecule ) rating. THis affects how they are absorbed/used. This is the problem with feed throughs. The size of molecule it takes to make it past the stomach is to big to be absorbed in the GI tract. This is why Lubrisyn claims theirs is absorbed before it even gets to the stomach. Another option is Nex HA. Its identical to Legend and is APPROVED by the FDA for IV use. Just like Legend. As for Long term? All IV HA products last in a horse's system about 72 hours and are gone, they are not designed to have long term effects unless injected directly into the joint.
Does this mean that I'm wasting money giving a loading dose? Should I just give it before weekend shows? |
|
| |
|
Expert
Posts: 1611
| Longneck - 2015-04-16 9:59 AM
FLITASTIC - 2015-04-10 10:25 AM astreakinchic - 2015-04-06 8:31 AM I've ordered this before made by Hytryl its off label use. http://www.allvetsupply.com/hy5x6mlvi.html It works the same as legend as far as giving before a big show. If I had the money to give it every time through the gate I would but I must be economical. I'm not a pentosan fan although I have used it. Does paying more for the higher price of legend have any long term benefits? I've used off labels and had the same results as the real thing....wondering if there are any long term benefits to the higher molecular weight HA? I have used Hytryl and Legend interchangeably. And not all HA's are the same. THey differ in their Dalton ( Size of molecule ) rating. THis affects how they are absorbed/used. This is the problem with feed throughs. The size of molecule it takes to make it past the stomach is to big to be absorbed in the GI tract. This is why Lubrisyn claims theirs is absorbed before it even gets to the stomach. Another option is Nex HA. Its identical to Legend and is APPROVED by the FDA for IV use. Just like Legend. As for Long term? All IV HA products last in a horse's system about 72 hours and are gone, they are not designed to have long term effects unless injected directly into the joint.
It lasts 72 hours point blank. If you have money give it every shot through the gate if you must be economically give it at big shows. I've heard some dog and cat vets say one shot a month...well after 72 hrs that one shot is gone. Since this thread I've talked to expert lameness vets who say to give it the morning or the day before...one theorizes at 5 hours your at peak effectiveness. I personally know futurity trainers who will get up at 4:30 the day of a run to give a shot of HA. Play with the timing and see what gives you the best results.
Edited by astreakinchic 2015-04-16 9:05 AM
|
|
| |
|
Rad Dork
Posts: 5218
Location: Oklahoma | astreakinchic - 2015-04-16 9:01 AM Longneck - 2015-04-16 9:59 AM FLITASTIC - 2015-04-10 10:25 AM astreakinchic - 2015-04-06 8:31 AM I've ordered this before made by Hytryl its off label use. http://www.allvetsupply.com/hy5x6mlvi.html It works the same as legend as far as giving before a big show. If I had the money to give it every time through the gate I would but I must be economical. I'm not a pentosan fan although I have used it. Does paying more for the higher price of legend have any long term benefits? I've used off labels and had the same results as the real thing....wondering if there are any long term benefits to the higher molecular weight HA? I have used Hytryl and Legend interchangeably. And not all HA's are the same. THey differ in their Dalton ( Size of molecule ) rating. THis affects how they are absorbed/used. This is the problem with feed throughs. The size of molecule it takes to make it past the stomach is to big to be absorbed in the GI tract. This is why Lubrisyn claims theirs is absorbed before it even gets to the stomach. Another option is Nex HA. Its identical to Legend and is APPROVED by the FDA for IV use. Just like Legend. As for Long term? All IV HA products last in a horse's system about 72 hours and are gone, they are not designed to have long term effects unless injected directly into the joint. It lasts 72 hours point blank. If you have money give it every shot through the gate if you must be economically give it at big shows. I've heard some dog and cat vets say one shot a month...well after 72 hrs that one shot is gone. Since this thread I've talked to expert lameness vets who say to give it the morning or the day before...one theorizes at 5 hours your at peak effectiveness. I personally know futurity trainers who will get up at 4:30 the day of a run to give a shot of HA. Play with the timing and see what gives you the best results.
Thanks, I'll refrain from using it right away. Just in the process of legging back up. |
|
| |
|
boon
Posts: 1
| FLITASTIC - 2015-04-10 9:25 AM
astreakinchic - 2015-04-06 8:31 AM
I've ordered this before made by Hytryl its off label use. http://www.allvetsupply.com/hy5x6mlvi.html
It works the same as legend as far as giving before a big show. If I had the money to give it every time through the gate I would but I must be economical.
I'm not a pentosan fan although I have used it.
Does paying more for the higher price of legend have any long term benefits? I've used off labels and had the same results as the real thing....wondering if there are any long term benefits to the higher molecular weight HA?
I have used Hytryl and Legend interchangeably. And not all HA's are the same. THey differ in their Dalton ( Size of molecule ) rating. THis affects how they are absorbed/used. This is the problem with feed throughs. The size of molecule it takes to make it past the stomach is to big to be absorbed in the GI tract. This is why Lubrisyn claims theirs is absorbed before it even gets to the stomach. Another option is Nex HA. Its identical to Legend and is APPROVED by the FDA for IV use. Just like Legend.
As for Long term? All IV HA products last in a horse's system about 72 hours and are gone, they are not designed to have long term effects unless injected directly into the joint.
If you are looking for a long term solution HyalunPRO is an awesome product. It's an oral dosage, but is a liquid so you get a better absorption and you don't get any of the worries of injection. I use it on all 3 of mine, my dog, and myself.
This link tells you more about the product.
http://hyalogic.com/equine_care/hyalogic_what_is_hyalun_pro_hyaluro...
|
|
| |
|
Expert
Posts: 1611
| CowgirlColey21 - 2015-04-20 2:02 PM
FLITASTIC - 2015-04-10 9:25 AM
astreakinchic - 2015-04-06 8:31 AM
I've ordered this before made by Hytryl its off label use. http://www.allvetsupply.com/hy5x6mlvi.html
It works the same as legend as far as giving before a big show. If I had the money to give it every time through the gate I would but I must be economical.
I'm not a pentosan fan although I have used it.
Does paying more for the higher price of legend have any long term benefits? I've used off labels and had the same results as the real thing....wondering if there are any long term benefits to the higher molecular weight HA?
I have used Hytryl and Legend interchangeably. And not all HA's are the same. THey differ in their Dalton ( Size of molecule ) rating. THis affects how they are absorbed/used. This is the problem with feed throughs. The size of molecule it takes to make it past the stomach is to big to be absorbed in the GI tract. This is why Lubrisyn claims theirs is absorbed before it even gets to the stomach. Another option is Nex HA. Its identical to Legend and is APPROVED by the FDA for IV use. Just like Legend.
As for Long term? All IV HA products last in a horse's system about 72 hours and are gone, they are not designed to have long term effects unless injected directly into the joint.
If you are looking for a long term solution HyalunPRO is an awesome product. It's an oral dosage, but is a liquid so you get a better absorption and you don't get any of the worries of injection. I use it on all 3 of mine, my dog, and myself.
This link tells you more about the product.
http://hyalogic.com/equine_care/hyalogic_what_is_hyalun_pro_hyaluro...
I'm assuming this product claims to be absorbed b4 the stomach just as lubrisyn does?
Edited by astreakinchic 2015-04-20 1:31 PM
|
|
| |
Folks on-line